Abstract
Introduction. Studying psychoneurophysiological correlates in perimenopausal women is of great theoretical and practical importance, since it may help in identifying common and gender-specific patterns of aging. The menopausal syndrome and the neurophysiological substrate underlying the phenomena of psychological maladjustment in menopausal women merit special attention. This study reveals previously unknown neuro-energetic correlates of psycho-emotional characteristics of the climacteric syndrome.
Methods. This study involved menopausal women with and without manifestations of the menopausal syndrome and reproductive-age women with the normal menstrual cycle. Using the questioning method the authors examined the respondents’ personality traits. After averaging over groups, these personality characteristics were compared with the constant potential level (CPL) in frontal, central, occipital, right and left temporal regions of the cortex, which was registered by the Neuro-energo-cartograph NEC-5 hardware/software complex. The CPL was assessed by means of a special embedded math program. This helped to distinguish the local and the average CPLs, CPL gradients between unipolar values and to map the obtained data on the computer screen.
Results. The findings of the study indicated a positive correlation between the expression of situational anxiety and unmotivated aggressiveness and the increased CPL in the occipital and temporal cortex in women with the climacteric syndrome.
Discussion. For the first time in the study of the female climacterium, the use of registration and neuro-energetic mapping of the CPLs in various regions of the cerebral cortex and their correlations with psycho-emotional characteristics helped to identify the intensity and topography of energy metabolism in the brain, which is an integral neurophysiological substrate for psycho-emotional manifestations of the climacteric syndrome. The registration of the CPLs enabled authors to correlate the intensity and topography of energy metabolism in various regions of the cortex with psycho-emotional characteristics of the climacteric syndrome.
References
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Boban M., Črnac P, Junaković A., Malojčić B. Hemodynamic monitoring of middle arteries during cognitive performance. Psychiatry and Clinical Neurosciences, 2014, V. 68, Issue 11, pp. 795–803. DOI: http://dx.doi.org/10.1111/pcn.12191
Dyck P. J., Argyros B., Russell J. W., et al. Multicenter trial of the proficiency of smart quantitative sensation tests. Muscle & Nerve, 2014, V. 49, Issue 5, pp. 645–653. DOI: http://dx.doi.org/10.1002/mus.23982
Schaworonkow N., Triesch J., Ziemann U., Zrenner C. EEG-triggered TMS reveals stronger brain state-dependent modulation of motor evoked potentials at weaker stimulation intensities. Brain stimulation, 2019, V. 12, Issue 1, pp. 110–118. DOI: http://dx.doi.org/10.1016/j.brs.2018.09.009
Boravova A. I., Ponomareva N. V., Fokin V. F. Correlation between dynamic interhemispheric asymmetry and anxiety in adolescents with various orientations of achievement motivation. Asimmetriya – Asymmetry, 2017, V. 11, no. 2, pp. 54–64 (in Russian).
Boravova A. I., Galkina N. S., Fokin V. F. Characteristics of the CPL of the brain in adolescent aggression. Asimmetriya – Asymmetry, 2011, V. 5, no. 4, pp. 39–50 (in Russian).
Baron F, Binder A, Wasner G. Neuropathic pain: Diagnosis, pathophysiological mechanisms, and treatment. The Lancet Neurology, 2010, V. 9, Issue 8, pp. 807–819. DOI: http://dx.doi.org/10.1016/S1474-4422(10)70143-5
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Hickey M., Schoenaker D. A., Joffe H., et al. Depressive symptoms across the menopause transition: findings from a large population-based cohort study. Menopause, 2016, V. 23 (12), pp. 1287–1293. DOI: http://dx.doi.org/10.1097/GME.0000000000000712
Maki P., Freeman E., Greendale G., et al. Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition. Menopause, 2010, V. 17 (4), pp. 815–822. DOI: http://dx.doi.org/10.1097/gme.0b013e3181d763d2
Antonova A. A., Bachilo E. V., Baryl'nik Yu. B. Modern view on the problem of the development of mental disorders in perimenopausal women (review). Saratovskii nauchno-meditsinskii zhurnal – Saratov Scientific Medical Journal, 2012, V. 8, no. 2, pp. 379–383 (in Russian).
Lebedev D. A., Chernositov A. V., Botasheva T. L. Characteristics of the psychological status of women of perimenopausal women with manifestations of the menopausal syndrome. Rossiiskii psikhologicheskii zhurnal – Russian Psychological Journal, 2017, V. 14, no. 4, pp. 121–137 (in Russian). DOI: http://dx.doi.org/10.21702/rpj.2017.4.6
Nikiforov G. S. Diagnostika zdorov'ya. Psikhologicheskii praktikum [Diagnosis of health. Psychological tutorial]. St. Petersburg, Rech' Publ., 2013. 950 p.
Bauer H., Korunka C., Leodolter M. Technical requirements for high-quality scalp DC recordings. Electroencephalography and Clinical Neurophysiology, 1989, V. 72, no. 6, pp. 545–547.
Fokin V. F., Ponomareva N. V. Dynamic characteristics of functional interhemispheric asymmetry. In: N. N. Bogolepova, V. F. Fokina (eds.) Funktsional'naya mezhpolusharnaya asimmetriya [Functional interhemispheric asymmetry]. Moscow, Nauchnyi mir, 2004, pp. 1–26.
Fokin V. F., Ponomareva N. V. Energeticheskaya fiziologiya mozga [Energy physiology of the brain]. Moscow, Antidor Publ., 2003. 288 p.
Mironov N. V., Mkrtchyan N. S., Zaitseva A. Yu., Perepelitsyna Yu. V., Yazvenko A. V., Shmyrev V. I. Functional and metabolic hemispheric asymmetry of the brain. Kremlevskaya meditsina. Klinicheskii vestnik – Kremlin Medicine. Clinical Bulletin, 2006, no. 1, pp. 9–12 (in Russian).
Shmyrev V. I. et al. Neuro-energetic mapping as a highly informative method of assessing the functional state of the brain. The data on neuro-energetic mapping in cognitive impairment and decreased mental capacity: guideline. Moscow, 2010. Available at: http://mkp2015.ru/docs/amea-neuro.pdf (Accessed 23 July 2018).
Shmyrev V. I., Mironov N. V., Mkrtchyan N. S., Zaitseva A. Yu., Vit'ko N. K., Mironov I. N. Energy metabolism of the brain and its study using positron emission tomography. Kremlevskaya meditsina. Klinicheskii vestnik – Kremlin Medicine. Clinical Bulletin, 2006, no. 1, pp. 7–9 (in Russian).
Deputat I. S., Gribanov A. V., Nekhoroshkova A. N., Startseva L. F., Bol'shevidtseva I. L. Energy state of the brain in elderly women living in the North. Ekologiya cheloveka – Human Ecology, 2016, no. 9, pp. 40–45 (in Russian).
Fokin V. F., Medvedev R. B., Ponomareva N. V. et al. Lateralization of bilateral blood flow through the central and peripheral arteries in cognitive loads in patients with dyscirculatory encephalopathy. Asimmetriya – Asymmetry, 2018, V. 12, no. 2, pp. 74–84 (in Russian).
Mironov N. P., Sokolova L. P., Borisova Yu. V. Neuro-energetic mapping: Assessing the functional state of the brain in cognitive disorders of various etiologies. Vestnik MEDSI – MEDSI Bulletin, 2010, no. 8, pp. 32–37 (in Russian).
Mikheev N. N. et al. Identifying neurometabolism in patients with mild and moderate cognitive impairment. Vestnik rentgenologii i radiologii – Journal of Roentgenology and Radiology, 2016, no. 2, pp. 15–22 (in Russian).
Mikheev N. N., Borisova Yu. V. Instrumental diagnostics of neurometabolism in pre-dementia cognitive disorders in young and middle-aged patients. Meditsinskii vestnik MVD – Medical Bulletin of the Ministry of Internal Affairs, 2010, no. 6, pp. 30–33 (in Russian).
Safonicheva M. A., Safonicheva O. G., Minenko I. A., Koekina O. I. Neurological and neurophysiological study of children with intellectual impairment. Vestnik novykh meditsinskikh tekhnologii – Journal of New Medical Technologies, 2011, V. 18, no. 3, pp. 238–241 (in Russian).
Sokolova L. P. Functional activity of the brain and neurometabolism in cognitive disorders of various geneses. Fundamental'nye issledovaniya – Fundamental Research, 2011, V. 1, no. 11, pp. 131–136 (in Russian).
Sokolova L. P., Shmyrev V. I. Certain characteristics of metabolism and functional activity of the brain in cognitive disorders of various geneses: A theoretical review. Profilakticheskaya i klinicheskaya meditsina – Preventive and Clinical Medicine, 2011, no. 3, pp. 134–144 (in Russian).
Sokolova L. P., Shmyrev V. I., Vitko N. K. Brain metabolism and neuro-energetic mapping in cognitive disorders of various geneses. Kremlevskaya meditsina. Klinicheskii vestnik – Kremlin Medicine. Clinical Bulletin, 2014, no. 2, pp. 18–22 (in Russian).
Sokolova L. P. Functional cognitive disorders. Vrach – The Doctor, 2011, no. 7, pp. 10–12 (in Russian).
Spiridonova M. S., Chereneva E. A., Masloboev S. G., Muller T. A., Skripnikova I. P., Lisova N. A. Certain hematological and immune disorders in children with autism spectrum disorder. Kompleksnye issledovaniya cheloveka: psikhologiya – Comprehensive Study of Human: Psychology. Tomsk, TSU Publ., 2017, pp. 140–142 (in Russian).
Baba-Zade A. A., Ozolin N. N., Fokin V. F. et al. Analyzing the level of constant potential of the brain as a method of operational and current control of athletes. Teoriya i praktika fizicheskoi kul'tury – Theory and Practice of Physical Culture, 1989, no. 5, pp. 42–64 (in Russian).
Ovsyannikova M. A., Bindusov E. E. Assessing the efficiency of physical education university classes by the impact on female students’ central nervous system. Fizicheskaya kul'tura: vospitanie, obrazovanie, trenirovka – Physical Culture: Upbringing, Education, Training, 2013, no. 1, pp. 21–23 (in Russian).
Kirsanov V. M., Kaigorodov B. V. (ed.) Primenenie metoda omegametrii (diagnostika urovnya postoyannogo potentsiala) i neiroenergokartirovaniya golovnogo mozga dlya diagnostiki stressovogo sostoyaniya [Application of the method of omegametry (diagnosis of the level of constant potential) and brain energy mapping for the diagnosis of stress]. Professional'nyi i organizatsionnyi stress: diagnostika, profilaktika i korrektsiya: materialy Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem [Professional and organizational stress: Diagnosis, prevention and correction: Proc. the All-Russian Theoretical and Practical Conference with International Participation]. Astrakhan, Astrakhan State University Publ., 2011, pp. 20–22.
Chernositov A. V. Funktsional'naya asimmetriya mozga: mediko-biologicheskie, psikhologicheskie i sotsial'no-pedagogicheskie aspekty [Functional asymmetry of the brain: Medico-biological, psychological, and socio-pedagogical aspects]. Rostov-on-Don, SFU Publ., 2011. 184 p.
Chernositov A. V., Orlov V. I. Functional asymmetry and nonspecific resistance. In: Bogolepova N. N., Fokina V. F. (eds.) Funktsional'naya mezhpolusharnaya asimmetriya [Functional hemispheric asymmetry]. Moscow, Nauchnyi mir Publ., 2004, pp. 700–748.
Pavlenko V. B., Dyagileva Yu. O., Mikhailova A. A., Belalov V. V., Makhin S. A., Eismont E. V. Interrelation between reactivity of the EEG sensorimotor rhythm and psychological characteristics of children and adults. Zhurnal fundamental'noi meditsiny i biologii – Journal of Fundamental Medicine and Biology, 2016, no. 2, pp. 30–36 (in Russian).
Boban M., Črnac P, Junaković A., Malojčić B. Hemodynamic monitoring of middle arteries during cognitive performance. Psychiatry and Clinical Neurosciences, 2014, V. 68, Issue 11, pp. 795–803. DOI: http://dx.doi.org/10.1111/pcn.12191
Dyck P. J., Argyros B., Russell J. W., et al. Multicenter trial of the proficiency of smart quantitative sensation tests. Muscle & Nerve, 2014, V. 49, Issue 5, pp. 645–653. DOI: http://dx.doi.org/10.1002/mus.23982
Schaworonkow N., Triesch J., Ziemann U., Zrenner C. EEG-triggered TMS reveals stronger brain state-dependent modulation of motor evoked potentials at weaker stimulation intensities. Brain stimulation, 2019, V. 12, Issue 1, pp. 110–118. DOI: http://dx.doi.org/10.1016/j.brs.2018.09.009
Boravova A. I., Ponomareva N. V., Fokin V. F. Correlation between dynamic interhemispheric asymmetry and anxiety in adolescents with various orientations of achievement motivation. Asimmetriya – Asymmetry, 2017, V. 11, no. 2, pp. 54–64 (in Russian).
Boravova A. I., Galkina N. S., Fokin V. F. Characteristics of the CPL of the brain in adolescent aggression. Asimmetriya – Asymmetry, 2011, V. 5, no. 4, pp. 39–50 (in Russian).
Baron F, Binder A, Wasner G. Neuropathic pain: Diagnosis, pathophysiological mechanisms, and treatment. The Lancet Neurology, 2010, V. 9, Issue 8, pp. 807–819. DOI: http://dx.doi.org/10.1016/S1474-4422(10)70143-5
Dzugaeva I. O., Abdullaeva S. S., Shipievskii B. M. Prevention and treatment of the climacteric syndrome in postmenopausal women. Vestnik RUDN. Ser. “Meditsina” – RUDN Journal of Medicine, 2008, no. 5, pp. 220–227 (in Russian).
Hickey M., Schoenaker D. A., Joffe H., et al. Depressive symptoms across the menopause transition: findings from a large population-based cohort study. Menopause, 2016, V. 23 (12), pp. 1287–1293. DOI: http://dx.doi.org/10.1097/GME.0000000000000712
Maki P., Freeman E., Greendale G., et al. Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition. Menopause, 2010, V. 17 (4), pp. 815–822. DOI: http://dx.doi.org/10.1097/gme.0b013e3181d763d2
Antonova A. A., Bachilo E. V., Baryl'nik Yu. B. Modern view on the problem of the development of mental disorders in perimenopausal women (review). Saratovskii nauchno-meditsinskii zhurnal – Saratov Scientific Medical Journal, 2012, V. 8, no. 2, pp. 379–383 (in Russian).
Lebedev D. A., Chernositov A. V., Botasheva T. L. Characteristics of the psychological status of women of perimenopausal women with manifestations of the menopausal syndrome. Rossiiskii psikhologicheskii zhurnal – Russian Psychological Journal, 2017, V. 14, no. 4, pp. 121–137 (in Russian). DOI: http://dx.doi.org/10.21702/rpj.2017.4.6
Nikiforov G. S. Diagnostika zdorov'ya. Psikhologicheskii praktikum [Diagnosis of health. Psychological tutorial]. St. Petersburg, Rech' Publ., 2013. 950 p.
Bauer H., Korunka C., Leodolter M. Technical requirements for high-quality scalp DC recordings. Electroencephalography and Clinical Neurophysiology, 1989, V. 72, no. 6, pp. 545–547.