Abstract
Studying the correlation between the characteristics of the structure of genes and the parameters of the evoked brain activity is a relevant problem of modern research. It is known that the MAOA gene, which influences the concentration of such neurotransmitters-monoamines as dopamine, serotonin, and norepinephrine, is associated with different psychological characteristics. However, very little is known about the association of this gene with psycho-physiological indices. The purpose of the present study was to investigate the characteristics of amplitude and spatial-temporal characteristics of the evoked brain activity in girls (at the age from 18 to 24) who were carriers of different MAOA genotypes. According to the results of genotyping, the participants (61 persons) were divided into two groups: with the high-activity and heterozygous MAOA -uVNTR genotypes. In the study the authors
recorded visual evoked potentials in 64 derivations. Emotionally charged and neutral images were stimuli in the study.
The paper describes modern views on the correlation between MAOA genotypes and the features of cortico-limbic interaction. The results of the study showed that the heterozygous genotypes were apparently associated with lesser efficiency of regulating functions. To activate neural systems of the frontal divisions the female carriers of the heterozygous genotypes of MAOA needed the stimuli with a high arousal effect; this can be connected with a less efficient process of selecting relevant stimuli. At the same time, the high-activity MAOA genotypes in women are probably associated with high efficiency of controlling functions (attention, planning, control) of the prefrontal cortex when assessing emotionally charged images, which is accompanied by the intensity of activation of these brain structures.
References
Alfimova M. V., Golimbet V. E. Geny i neirofiziologicheskie pokazateli kognitivnykh protsessov: obzor issledovanii [Genes and neurophysiological characteristics of cognitive processes: a review of research]. Zhurnal vysshei nervnoi deyatel'nosti im. I. P. Pavlova – I. P. Pavlov Journal of Higher Nervous Activity, 2011, V. 61, no. 4, pp. 389–401.
Alfimova M. V., Golimbet V. E., Egorova M. S. Lichnostnye cherty, upravlyayushchie funktsii i geneticheskie osobennosti metabolizma monoaminov [Personality traits, control functions, and genetic characteristics of monoamine metabolism]. Psikhologiya. Zhurnal Vysshei shkoly ekonomiki – Psychology. Journal of the Higher School of Economics, 2009, V. 6, no. 4.
Alfimova M. V., Golimbet V. E., Lebedeva I. S., Korovaitseva G. I., Lezheiko T. V. Vliyanie trevozhnosti i gena COMT na vyzvannye potentsialy mozga i produktivnost' izbiratel'nogo vnimaniya [The influence of anxiety and the COMT gene on evoked potentials and the productivity of selective attention]. Zhurnal vysshei nervnoi deyatel'nosti im. I. P. Pavlova – I. P. Pavlov Journal of Higher Nervous Activity, 2014, V. 64, no. 3, P. 270. Doi:10.7868/s0044467714030034
Bogdanova I. V. Rol' dofamina v mekhanizmakh formirovaniya nekotorykh rasstroistv TsNS i sostoyanii zavisimosti (obzor literatury) [The role of dopamine in the mechanisms of formation of certain disorders of the central nervous system and states of addiction (a literature survey)]. Ukraїns'kii vіsnik psikhonevrologії – Ukrainian Bulletin of Psychoneurology, 2011, no. 19, V. 2, pp. 5–8.
Egorova M. S., Chertkova Yu. D. The monoamine oxidase (MAOA) gene polymorphism and the variability of psychological traits. Psychological research, 2011, no. 6 (20), P. 14. Available at: http://psystudy.ru
Kovalenko A. A., Pavlenko V. B. Emotsional'naya znachimost' stimula i cherty lichnosti: otrazhenie v patterne vyzvannykh EEG-potentsialov [Emotional significance of the stimulus and personality traits: the reflections in the pattern of evoked EEG potentials]. Neirofiziologiya – Neurophysiology, 2009, pp. 336–356.
Shabanov P. D., Lebedev A. A. Neirokhimicheskie mekhanizmy prilezhashchego yadra, realizuyushchie podkreplyayushchie effekty samostimulyatsii lateral'nogo gipotalamusa [The neurochemical mechanisms of the nucleus accumbens carrying out reinforcing effects of lateral hypothalamic self-stimulation]. Meditsinskii akademicheskii zhurnal – Medical Academic Journal, 2012, V. 12, no. 2, pp. 68–76.
Barnes J. M., Dean A. J., Nandam L. S., O'Connell R. G., Bellgrove M. A.The Molecular Genetics of Executive Function: Role of Monoamine System Genes.Biological Psychiatry, 2011, V. 69, I. 12, pp. 127–143. Doi:10.1016/j.biopsych.2010.12.040
Barnett J. H., Xu K., Heron J., Goldman D., Jones P. B.Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA and 5HTTLPR.American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 2011, V. 156, pp. 158–167. Doi:10.1002/ajmg.b.31150
Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. Ed. by Brady S.T. et al. Academic press / Elsevier, 2012. 1096 p. Doi:10.1212/wnl.39.3.460-b
Battaglia M. Challenges in the appraisal and application of gene-environment interdependence. European Journal of Developmental Psychology, 2012,V. 9, no. 4, pp. 419–425. Doi:10.1080/17405629.2012.689819
Beach S. R., Brod G. H., Gunter T. D., Packer H., Wernett P., Philibert R. A. Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.Journal of Family Psychology, 2010,V. 24 (1), pp. 12–20. doi:10.1037/a0018074
Bishop S. J. Trait anxiety and impoverished prefrontal control of attention.Nature neuroscience, 2009, V. 12, no. 1, pp. 92–98. Doi:10.1038/nn.2242
Buckholtz J., Callicott J., Kolachana B., Hariri A., Goldberg T., Genderson M. Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality.Molecular Psychiatry, 2008, V. 13, pp. 313–324. Doi:10.1038/sj.mp.4002020
Buckholtz J. W., Meyer-Lindenberg A. MAOA and the neurogenetic architecture of human aggression.Trends in neurosciences, 2008, V. 31.3, pp. 120–129. Doi:10.1016/j.tins.2007.12.006
Cacioppo J. T., Crites S. L., Gardner W. L. Attitudes to the right: Evaluative processing is associated with lateralized late positive event-related brain potentials.Personality and Social Psychology Bulletin, 1996,V. 22, no. 12, pp. 1205–1219. Doi:10.1177/01461672962212002
Cerasa A., Gioia M. C., Fera F., Passammonti L., Liguori M., Lanza P., Muglia M., Maagariello A., Quattrone A. Ventrolateral prefrontal activity during working memory is modulated by MAO A genetic variation. Brain Res., 2008,V. 1201, pp. 114–121. Doi:10.1016/j.brainres.2008.01.048
Chen C. H., Fiecas M., Gutierrez E. D., Panizzon M. S., Eyler L. T., Vuoksimaa E., Neale M. C. Genetic topography of brain morphology.Proceedings of the National Academy of Sciences, 2013, V. 110, no. 42, pp. 17089–17094. Doi:10.1073/pnas.1308091110
Chen J., Lipska B. K., Halim N., Ma Q. D., Matsumoto M., Melhem S. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain.The American Journal of Human Genetics, 2004,V. 75 (5), pp. 807–821. doi:10.1086/425589
Delplanque S., Lavoie M. E., Hot P., Silvert L., Sequeira H. Modulation of cognitive processing by emotional valence studied through event-related potentials in humans.Neuroscience letters, 2004, V. 356, no. 1, pp. 1–4. Doi:10.1016/j.neulet.2003.10.014
Domschke K., Dannlowski U. Imaging genetics of anxiety disorders.Neuroimage, 2010, V. 53, no. 3, pp. 822–831. Doi:10.1093/med/9780199920211.003.0014
Ficks C. A., Waldman I. D. Candidate genes for aggression and antisocial behavior: a meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR. Behav Genet., 2014,V. 44 (5), pp. 427–444. Doi:10.1007/s10519-014-9661-y
Fossella J., Sommer T., Fan J., Wu Y., Swanson J. M., Pfaff D. W., Posner M. I. Assessing the molecular genetics of attention networks.BMC Neuroscience, 2002,V. 3, pp. 14–19. Doi:10.1002/9780470015902.a0006012.pub2
Goldman D., Oroszi G., Ducci F. The genetics of addictions: Uncovering the genes.Nature Reviews Genetics, 2005,V. 6 (7), pp. 521–532. doi:10.1038/nrg1635
Kayser J., Bruder G. E., Tenke C. E., Stewart J. E., Quitkin F. M. Event-related potentials (ERPs) to hemifield presentations of emotional stimuli: differences between depressed patients and healthy adults in P3 amplitude and asymmetry.International Journal of Psychophysiology, 2000, V. 36, no. 3, pp. 211–236. Doi:10.1016/0304-3940(93)90241-c
Morgan M. A., Romanski L. M., LeDoux J. E. Extinction of emotional learning: contribution of medial prefrontal cortex.Neuroscience letters, 1993, V. 163, no. 1, pp. 109–113. Doi:10.1016/0304-3940(93)90241-c
Olofsson J. K.,Nordin S., Sequeira H., Polich J. Affective picture processing: an integrative review of ERP findings.Biological psychology, 2008, V. 77, no. 3, pp. 247–265.Doi:10.1016/j.biopsycho.2007.11.006
Pardini M., Krueger F., Hodgkinson C., Raymont V., Ferrier C., Goldman D., Grafman J. Prefrontal cortex lesions and MAO-A modulate aggression in penetrating traumatic brain injury.Neurology,2011,V. 76 (12), pp. 1038–1045. http://doi.org/10.1212/WNL.0b013e318211c33e
Passamonti L., Fera F., Magariello A., Ceerasa A., Gioia M. C., Muglia M., Nicoletti G., Gallo O., Provinciali L., Quattrone A. Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity.Biol. Psychiatry, 2006,V. 59, pp. 334–340. Doi:10.1016/j.biopsych.2005.07.027
Smolka M. N., Schumann G., Wrase J., Grüsser S. M., Flor H., Mann K., Heinz A. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.The Journal of neuroscience, 2005, V. 25, no. 4, pp. 836–842. Doi:10.1523/jneurosci.1792-04.2005
Takahashi A., Quadros I. M., de Almeida R. M., Miczek K. A. Behavioral and pharmacogenetics of aggressive behavior.Behavioral Neurogenetics. Current Topics in Behavioral Neurosciences, 2012, V. 12, pp. 73–138.Doi:10.1007/7854_2011_191
Talsma D., Mulckhuyse M., Slagter H. A., Theeuwes J. Faster, more intense! The relation between electrophysiological reflections of attentional orienting, sensory gain control, and speed of responding.Brain Research, 2007, V. 1178, pp. 92–105. Doi:10.1016/j.brainres.2007.07.099
Taylor M. J. Non-spatial attentional effects on P1.Clin. Neurophysiol., 2002, V. 113, no. 12, pp. 1903–1908. Doi:10.1016/s1388-2457(02)00309-7
Weeland J., Overbeek G., de Castro B. O., & Matthys W. Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review, 2015, V. 18, no. 4, pp. 413–442. http://doi.org/10.1007/s10567-015-0196-4
Williams L. M., Gatt J. M., Kuan S. A., Dobson-Stone C., Palmer D. M., Paul R. H., Le Song, Costa P. T., Schofield P. R., Gordon E. A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index.Neuropsychopharmacology, 2009, no. 34, pp. 1797–1809. Doi:10.1038/npp.2009.1
Ziermans T., Dumontheil I., Roggeman C., Peyrard-Janvid M., Matsson H., Kere J., Klingberg T. Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development.Citation: Transl. Psychiatry, 2012, V. 2, P. 1038.Doi:10.1038/tp.2012.7
Alfimova M. V., Golimbet V. E., Egorova M. S. Lichnostnye cherty, upravlyayushchie funktsii i geneticheskie osobennosti metabolizma monoaminov [Personality traits, control functions, and genetic characteristics of monoamine metabolism]. Psikhologiya. Zhurnal Vysshei shkoly ekonomiki – Psychology. Journal of the Higher School of Economics, 2009, V. 6, no. 4.
Alfimova M. V., Golimbet V. E., Lebedeva I. S., Korovaitseva G. I., Lezheiko T. V. Vliyanie trevozhnosti i gena COMT na vyzvannye potentsialy mozga i produktivnost' izbiratel'nogo vnimaniya [The influence of anxiety and the COMT gene on evoked potentials and the productivity of selective attention]. Zhurnal vysshei nervnoi deyatel'nosti im. I. P. Pavlova – I. P. Pavlov Journal of Higher Nervous Activity, 2014, V. 64, no. 3, P. 270. Doi:10.7868/s0044467714030034
Bogdanova I. V. Rol' dofamina v mekhanizmakh formirovaniya nekotorykh rasstroistv TsNS i sostoyanii zavisimosti (obzor literatury) [The role of dopamine in the mechanisms of formation of certain disorders of the central nervous system and states of addiction (a literature survey)]. Ukraїns'kii vіsnik psikhonevrologії – Ukrainian Bulletin of Psychoneurology, 2011, no. 19, V. 2, pp. 5–8.
Egorova M. S., Chertkova Yu. D. The monoamine oxidase (MAOA) gene polymorphism and the variability of psychological traits. Psychological research, 2011, no. 6 (20), P. 14. Available at: http://psystudy.ru
Kovalenko A. A., Pavlenko V. B. Emotsional'naya znachimost' stimula i cherty lichnosti: otrazhenie v patterne vyzvannykh EEG-potentsialov [Emotional significance of the stimulus and personality traits: the reflections in the pattern of evoked EEG potentials]. Neirofiziologiya – Neurophysiology, 2009, pp. 336–356.
Shabanov P. D., Lebedev A. A. Neirokhimicheskie mekhanizmy prilezhashchego yadra, realizuyushchie podkreplyayushchie effekty samostimulyatsii lateral'nogo gipotalamusa [The neurochemical mechanisms of the nucleus accumbens carrying out reinforcing effects of lateral hypothalamic self-stimulation]. Meditsinskii akademicheskii zhurnal – Medical Academic Journal, 2012, V. 12, no. 2, pp. 68–76.
Barnes J. M., Dean A. J., Nandam L. S., O'Connell R. G., Bellgrove M. A.The Molecular Genetics of Executive Function: Role of Monoamine System Genes.Biological Psychiatry, 2011, V. 69, I. 12, pp. 127–143. Doi:10.1016/j.biopsych.2010.12.040
Barnett J. H., Xu K., Heron J., Goldman D., Jones P. B.Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA and 5HTTLPR.American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 2011, V. 156, pp. 158–167. Doi:10.1002/ajmg.b.31150
Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. Ed. by Brady S.T. et al. Academic press / Elsevier, 2012. 1096 p. Doi:10.1212/wnl.39.3.460-b
Battaglia M. Challenges in the appraisal and application of gene-environment interdependence. European Journal of Developmental Psychology, 2012,V. 9, no. 4, pp. 419–425. Doi:10.1080/17405629.2012.689819
Beach S. R., Brod G. H., Gunter T. D., Packer H., Wernett P., Philibert R. A. Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.Journal of Family Psychology, 2010,V. 24 (1), pp. 12–20. doi:10.1037/a0018074
Bishop S. J. Trait anxiety and impoverished prefrontal control of attention.Nature neuroscience, 2009, V. 12, no. 1, pp. 92–98. Doi:10.1038/nn.2242
Buckholtz J., Callicott J., Kolachana B., Hariri A., Goldberg T., Genderson M. Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality.Molecular Psychiatry, 2008, V. 13, pp. 313–324. Doi:10.1038/sj.mp.4002020
Buckholtz J. W., Meyer-Lindenberg A. MAOA and the neurogenetic architecture of human aggression.Trends in neurosciences, 2008, V. 31.3, pp. 120–129. Doi:10.1016/j.tins.2007.12.006
Cacioppo J. T., Crites S. L., Gardner W. L. Attitudes to the right: Evaluative processing is associated with lateralized late positive event-related brain potentials.Personality and Social Psychology Bulletin, 1996,V. 22, no. 12, pp. 1205–1219. Doi:10.1177/01461672962212002
Cerasa A., Gioia M. C., Fera F., Passammonti L., Liguori M., Lanza P., Muglia M., Maagariello A., Quattrone A. Ventrolateral prefrontal activity during working memory is modulated by MAO A genetic variation. Brain Res., 2008,V. 1201, pp. 114–121. Doi:10.1016/j.brainres.2008.01.048
Chen C. H., Fiecas M., Gutierrez E. D., Panizzon M. S., Eyler L. T., Vuoksimaa E., Neale M. C. Genetic topography of brain morphology.Proceedings of the National Academy of Sciences, 2013, V. 110, no. 42, pp. 17089–17094. Doi:10.1073/pnas.1308091110
Chen J., Lipska B. K., Halim N., Ma Q. D., Matsumoto M., Melhem S. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain.The American Journal of Human Genetics, 2004,V. 75 (5), pp. 807–821. doi:10.1086/425589
Delplanque S., Lavoie M. E., Hot P., Silvert L., Sequeira H. Modulation of cognitive processing by emotional valence studied through event-related potentials in humans.Neuroscience letters, 2004, V. 356, no. 1, pp. 1–4. Doi:10.1016/j.neulet.2003.10.014
Domschke K., Dannlowski U. Imaging genetics of anxiety disorders.Neuroimage, 2010, V. 53, no. 3, pp. 822–831. Doi:10.1093/med/9780199920211.003.0014
Ficks C. A., Waldman I. D. Candidate genes for aggression and antisocial behavior: a meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR. Behav Genet., 2014,V. 44 (5), pp. 427–444. Doi:10.1007/s10519-014-9661-y
Fossella J., Sommer T., Fan J., Wu Y., Swanson J. M., Pfaff D. W., Posner M. I. Assessing the molecular genetics of attention networks.BMC Neuroscience, 2002,V. 3, pp. 14–19. Doi:10.1002/9780470015902.a0006012.pub2
Goldman D., Oroszi G., Ducci F. The genetics of addictions: Uncovering the genes.Nature Reviews Genetics, 2005,V. 6 (7), pp. 521–532. doi:10.1038/nrg1635
Kayser J., Bruder G. E., Tenke C. E., Stewart J. E., Quitkin F. M. Event-related potentials (ERPs) to hemifield presentations of emotional stimuli: differences between depressed patients and healthy adults in P3 amplitude and asymmetry.International Journal of Psychophysiology, 2000, V. 36, no. 3, pp. 211–236. Doi:10.1016/0304-3940(93)90241-c
Morgan M. A., Romanski L. M., LeDoux J. E. Extinction of emotional learning: contribution of medial prefrontal cortex.Neuroscience letters, 1993, V. 163, no. 1, pp. 109–113. Doi:10.1016/0304-3940(93)90241-c
Olofsson J. K.,Nordin S., Sequeira H., Polich J. Affective picture processing: an integrative review of ERP findings.Biological psychology, 2008, V. 77, no. 3, pp. 247–265.Doi:10.1016/j.biopsycho.2007.11.006
Pardini M., Krueger F., Hodgkinson C., Raymont V., Ferrier C., Goldman D., Grafman J. Prefrontal cortex lesions and MAO-A modulate aggression in penetrating traumatic brain injury.Neurology,2011,V. 76 (12), pp. 1038–1045. http://doi.org/10.1212/WNL.0b013e318211c33e
Passamonti L., Fera F., Magariello A., Ceerasa A., Gioia M. C., Muglia M., Nicoletti G., Gallo O., Provinciali L., Quattrone A. Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity.Biol. Psychiatry, 2006,V. 59, pp. 334–340. Doi:10.1016/j.biopsych.2005.07.027
Smolka M. N., Schumann G., Wrase J., Grüsser S. M., Flor H., Mann K., Heinz A. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.The Journal of neuroscience, 2005, V. 25, no. 4, pp. 836–842. Doi:10.1523/jneurosci.1792-04.2005
Takahashi A., Quadros I. M., de Almeida R. M., Miczek K. A. Behavioral and pharmacogenetics of aggressive behavior.Behavioral Neurogenetics. Current Topics in Behavioral Neurosciences, 2012, V. 12, pp. 73–138.Doi:10.1007/7854_2011_191
Talsma D., Mulckhuyse M., Slagter H. A., Theeuwes J. Faster, more intense! The relation between electrophysiological reflections of attentional orienting, sensory gain control, and speed of responding.Brain Research, 2007, V. 1178, pp. 92–105. Doi:10.1016/j.brainres.2007.07.099
Taylor M. J. Non-spatial attentional effects on P1.Clin. Neurophysiol., 2002, V. 113, no. 12, pp. 1903–1908. Doi:10.1016/s1388-2457(02)00309-7
Weeland J., Overbeek G., de Castro B. O., & Matthys W. Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review, 2015, V. 18, no. 4, pp. 413–442. http://doi.org/10.1007/s10567-015-0196-4
Williams L. M., Gatt J. M., Kuan S. A., Dobson-Stone C., Palmer D. M., Paul R. H., Le Song, Costa P. T., Schofield P. R., Gordon E. A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index.Neuropsychopharmacology, 2009, no. 34, pp. 1797–1809. Doi:10.1038/npp.2009.1
Ziermans T., Dumontheil I., Roggeman C., Peyrard-Janvid M., Matsson H., Kere J., Klingberg T. Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development.Citation: Transl. Psychiatry, 2012, V. 2, P. 1038.Doi:10.1038/tp.2012.7