Features of Memory Consolidation and Reconsolidation Processes in Patients With Cerebrovascular Disorders
PDF
PDF (Russian)

Keywords

visual-picturesque memory
semantic memory
memory consolidation
memory reconsolidation
cerebrovascular disorders
ischemic stroke
chronic cerebral ischemia
short-term memory
long-term memory
memory traces (engrams)

Abstract

Abstract: Introduction. Given the high prevalence of cerebral circulatory disorders (both acute and chronic), which are accompanied by a decrease in cognitive functions, for the most part, the effectiveness of rehabilitation and rehabilitation measures depends, among other things, on mnestic processes. The authors describe the characteristics of the memory consolidation and reconsolidation processes in patients with chronic (chronic cerebral ischemia) and acute (ischemic stroke in the circulation of the middle cerebral artery of hemispherical localization) disorders of the cerebral circulation. The study aimed to investigate the processes of consolidation and reconsolidation of memory in patients with impaired cerebral circulation (with acute and chronic cerebral ischemia). Methods. The research methods were methods of “10 words” and “Visual memory” by A. R. Luria, the experiment according to F. Bartlett’s scheme, methods of descriptive and comparative statistics. The total size of the research sample is 57 people aged 65.2 ± 2.78 years. The first group included patients with chronic cerebral ischemia – 21 people; the second group included the patients with left-sided localization of the ischemic stroke focus – 17 people; the third group also included patients who had suffered an ischemic stroke, 19 people – with the localization of the dextrocerebral affected area. Results. In patients with cerebral circulatory disorders, a decrease in short-term audio-verbal and visual-picturesque memory volume was revealed, regardless of the type of cerebral circulatory disorder (acute or chronic cerebral ischemia). In an ischemic stroke of hemispheric localization, a change in the qualitative and quantitative characteristics of the memory consolidation and reconsolidation processes has been experimentally proven. This change is a consequence of a decrease in the volume of short-term audio-verbal and visual-picturesque memory. Discussion. The decrease in volume leads to instability of the memory traces, which distorts the consolidated information. In the process of reconsolidation, there is a reduction (in case of chronic cerebral ischemia) and distortion (in case of ischemic stroke of hemispheric localization) of the reproduced information.

https://doi.org/10.21702/rpj.2022.3.4
PDF
PDF (Russian)

References

Alekseev, A. A., Rupchev, G. E., & Tkhostov, A. Sh. (2021). Planning disorders in schizophrenia: A potential role for short-term memory and attention. National Psychological Journal, 2, 51–60. https://doi.org/10.11621/npj.2021.0205 (in Russ.).

Anokhin, K. V. (2009). Long-term memory in the nervous system: Cellular and systemic mechanisms. In Scientific session MEPhI-2009. XI All-Russian scientific and technical conference “Neuroinformatics-2009”: Lectures on neuroinformatics (pp. 14–34). Moscow Engineering Physics Institute. (in Russ.).

Balaban, P. M. (2017). Molecular mechanisms of memory modification. Journal of Higher Nervous Activity, 67(2), 131–140. https://doi.org/10.7868/S0044467717020046 (in Russ.).

Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, R. M., Iemolo, F., Manfredi, M., Meco, G., Nicoletti, A., Pederzoli, M., Petrone, A., Pisani, A., Pontieri, F. E., Quatrale, R., Ramat, S., Scala, R., Volpe, G., Zappulla, S., Bentivoglio, A. R., Stocchi, F., Trianni, G., & Del Dotto, P. (2009). The PRIAMO Study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Movement Disorders, 24(11), 1641–1649. https://doi.org/10.1002/mds.22643

Bazyan, A. S. (2013). Molecular neurochemical and neurophysiological mechanisms of plasticity: Realization of behavior, learning, consolidation, storage and recall of memory. Advances in Physiological Sciences, 44(4), 3–23. (in Russ.).

Bellfy, L., & Kwapis, J. L. (2020). Molecular mechanisms of reconsolidation-dependent memory updating. International Journal of Molecular Sciences, 21(18). https://doi.org/10.3390/ijms21186580

Berganzo, K., Tijero, B., González-Eizaguirre, A., Somme, J., Lezcano, E., Gabilondo, I., Fernandez, M., Zarranz, J. J., & Gómez-Esteban, J. C. (2016). Motor and nonmotor symptoms of Parkinson’s disease and their impact on quality of life and on different clinical subgroups. Neurologia, 31(9), 585–591. https://doi.org/10.1016/j.nrleng.2014.10.016

Bizyuk, A. P. (2005). Compendium of neuropsychological research methods: Methodological guide. Rech’. (in Russ.).

Brefel-Courbon, C., Ory-Magne, F., Thalamas, C., Payoux, P., & Rascol, O. (2013). Nociceptive brain activation in patients with neuropathic pain related to Parkinson's disease. Parkinsonism and Related Disorders, 19(5), 548–552. https://doi.org/10.1016/j.parkreldis.2013.02.003

Griffiths, T. D., Lad, M., Kumar, S., Holmes, E., McMurray, B., Maguire, E. A., Billig, A. J., & Sedley, W. (2020). How can hearing loss cause dementia? Neuron, 108(3), 401–412. https://doi.org/10.1016/j.neuron.2020.08.003

Grigor'yan, G. A., & Markevich, V. A. (2014). Consolidation, reactivation and reconsolidation of memory. Journal of Higher Nervous Activity, 64(2), 123–136. https://doi.org/10.7868/S0044467714020087 (in Russ.).

Hegazy, R., Elheneidi, E. I., Elbalawy, Y., Hamoda, I. M., Said, M. T., & Mokhtar, M. M. (2022). Correlative study between memory deficits and upper extremity motor dysfunction in hemiplegic stroke patients. Clinical Schizophrenia & Related Psychoses, 16(1). https://doi.org/10.3371/CSRP.HREE.010522

Hou, J.-G. G., & Lai, E. C. (2007). Non-motor symptoms of Parkinson’s disease. International Journal of Gerontology, 1(2), 53–64. https://doi.org/10.1016/S1873-9598(08)70024-3

Jardine, K. H., Huff, A. E., Wideman, C. E., McGraw, S. D., & Winters, B. D. (2022). The evidence for and against reactivation-induced memory updating in humans and nonhuman animals. Neuroscience & Biobehavioral Reviews, 136. https://doi.org/10.1016/j.neubiorev.2022.104598

Kulesh, A. A., Emelin, A. Yu., Bogolepova, A. N., Doronina, O. B., Zakharov, V. V., Kolokolov, O. V., Kotov, S. V., Korsunskaya, L. L., Kutlubaev, M. A., Laskov, V. B., Levin, O. S., & Parfenov, V. A. (2021). Clinical manifestations and issues of diagnosis of chronic cerebrovascular disease (chronic cerebral ischemia) at an early (predemental) stage. Neurology, Neuropsychiatry, Psychosomatics, 13(1), 4–12. https://doi.org/10.14412/2074-2711-2021-1-4-12 (in Russ.).

Loughrey, D. G., Feeney, J., Kee, F., Lawlor, B. A., Woodside, J. V., Setti, A. & McHugh Power, J. (2021). Social factors may mediate the relationship between subjective age-related hearing loss and episodic memory. Aging & Mental Health, 25(5), 824–831. https://doi.org/10.1080/13607863.2020.1727847

Mastrorilli, V., Centofante, E., Antonelli, F., Rinaldi, A., & Mele, A. (2022). The neural substrate of spatial memory stabilization depends on the distribution of the training sessions. Neuroscience, 119(14). https://doi.org/10.1073/pnas.2120717119

Milton, A. L. (2022). Manipulating reconsolidation to weaken drug memory. In M. A. Aguilar (Ed.), Methods for preclinical research in addiction. Neuromethods (Vol. 174, pp. 315–330). Humana. https://doi.org/10.1007/978-1-0716-1748-9_13

Moorman, S. M., Greenfield, E. A., & Lee, C. S. H. (2020). Perceived hearing loss, social disengagement, and declines in memory. Journal of Applied Gerontology, 40(6), 679–683. https://doi.org/10.1177/0733464820909244

Nikishina, V. B., Petrash, E. A., Kuznetsova, A. A., Shuteeva, T. V., & Zakharova, I. A. (2021). Consolidation and reconsolidation of visual and semantic memory in Parkinson’s disease. Bulletin of Russian State Medical University, 6, 109–117. https://doi.org/10.24075/brsmu.2021.069

Nikishina, V. B., Petrash, E. A., Shuteeva, E. Yu., Sharashkina, N. V., & Zakharova, I. A. (2022). Visual-picturesque and semantic memory in Parkinson's disease: an analysis of clinical cases. Yakut Medical Journal, 1, 125–132. https://doi.org/10.25789/YMJ.2022.77.32 (in Russ.).

Nikitin, V. P., Solntseva, S. V., Kozyrev, S. A., & Nikitin, P. V. (2020). Long-term memory consolidation or reconsolidation impairment induces amnesia with key characteristics that are similar to key learning characteristics. Neuroscience and Biobehavioral Reviews, 108, 542–558. https://doi.org/10.1016/j.neubiorev.2019.12.005

Pan, D.-n., Hoid, D., Wolf, O. T., & Li, X. (2021). Brain activities of reconsolidation: Nuances in post-retrieval interference led to optimal alterations of episodic memories. Neurobiology of Learning and Memory, 185. https://doi.org/10.1016/j.nlm.2021.107531

Pourzinal, D., Yang, J. H. J., Bakker, A., McMahon, K. L., Byrne, G. J., Pontone, G. M., Mari, Z., & Dissanayaka, N. N. (2021). Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies. Journal of Neuroscience Research, 99(9), 2097–2116. https://doi.org/10.1002/jnr.24863

Rosemann, S., & Thiel, C. M. (2020). Neural signatures of working memory in age-related hearing loss. Neuroscience, 429, 134–142. https://doi.org/10.1016/j.neuroscience.2019.12.046

Siciliano, M., Trojano, L., Micco, R. D., Sant’Elia, V., Giordano, A., Russo, A., Passamonti, L., Tedeschi, G., Chiorri, C., & Tessitore, A. (2021). Correlates of the discrepancy between objective and subjective cognitive functioning in nondemented patients with Parkinson’s disease. Journal of Neurology, 268, 3444–3455. https://doi.org/10.1007/s00415-021-10519-4

Tikhomirova, T. N., Malykh, A. S., & Malykh, S. B. (2020). Visuospatial working memory development across years of schooling. Psychology in Russia: State of the Art, 13(4), 207–222. https://doi.org/10.11621/PIR.2020.0414

Velichkovskii, B. B. (2014). Working memory testing: from simple to complex and back to simple. Theoretical and Experimental Psychology, 7(2), 133–142. (in Russ.).

Velichkovskii, B. B. (2015). Human working memory: Structure and Mechanisms. Cogito-Centre. (in Russ.).

Yang, Y., Jie, J., Li, J., Chen, W., & Zheng, X. (2019). A novel method to trigger the reconsolidation of fear memory. Behaviour Research and Therapy, 122. https://doi.org/10.1016/j.brat.2019.103461

Zakharov, V. V., Vakhnina, N. V., Gogoleva, A. G., & Mezhmidinova, S. K. (2020). Diagnosis and treatment of chronic cerebral ischemia. Medical Council, 8, 36–45. https://doi.org/10.21518/2079-701X-2020-8-36-45 (in Russ.).

Zakharova, I. A., Petrash, E. A., Nikishina, V. B., Razuvaeva, T. N., & Shuteeva, T. V. (2022). Specific features of memory consolidation and reconsolidation in older individuals with vision and hearing impairments. Bulletin of Russian State Medical University, 2, 65–72. https://doi.org/10.24075/BRSMU.2022.018

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2022 Nikishina V. B., Petrash E. A., Zakharova I. A., Sotnikov V. A.